Molecules, Vol. 25, Pages 3547: The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes

Molecules, Vol. 25, Pages 3547: The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes Molecules doi: 10.3390/molecules25153547 Authors: Carla Junqueira Moragas-Tellis Fernando Almeida-Souza Maria do Socorro dos Santos Chagas Paulo Victor Ramos de Souza João Victor Silva-Silva Ygor Jessé Ramos Davyson de Lima Moreira Kátia da Silva Calabrese Maria Dutra Behrens Arrabidaea chica Verlot (crajiru) is a plant used in folk medicine as an astringent, anti-inflammatory, wound healing and to treat fungal and viral diseases such as measles chickenpox and herpes. Arrabidaea chica has several morphotypes recognized but little is known about its chemical variability. In the present study the anthocyanidin profile of A. chica morphotypes collected in two seasons (summer and winter) have been examined and their activity against Leishmania infection compared. High-performance liquid chromatography coupled to a diode-array detector (HPLC-DAD-UV) and by tandem mass spectrometry with electrospray ionization (ESI-MS/MS) were used for anthocyanidin separation and identification. Antileishmanial activity was measured against promastigote forms of Leishmania amazonensis. Multivariate analysis, principal component analysis (PCA) and Pearson’s correlation were performed to classify morphotypes accordingly to their anthocyanidin profile. The presence of 6,7,3′,4′-tetrahydroxy-5-metho...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research

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