Complexities of the Microbiome: Jaundice in Patient With Ulcerative Colitis

Patients with jaundice and abdominal pain should be assessed immediately for biliary obstruction. The development of cholangitis, or an inflammation of the bile ducts, can lead to infection. A nurse practitioner must complete a thorough health history and physical examination to assist in differentiating potential causes of jaundice.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Case Challenge Source Type: research

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This study examines intramuscular pressure in the trapezius as an alternative mechanism for understanding FMS pain. METHODS: 108 patients who satisfied the ACR criteria for FMS and 30 patients who met the ACR criteria for another rheumatic disease comprised the study groups. Muscle pressure was measured in mmHg using a pressure gauge attached to a No. 22 needle inserted into the mid portion of the trapezius muscle. In addition, FMS patients and rheumatic disease controls had dolorimetry testing, digital palpation, and reported pain scores. RESULTS: Muscle pressure was substantially higher in patients with FMS with ...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
PET/MRI helps clinicians stage cancer treatment as well as PET/CT -- and finds...Read more on AuntMinnie.comRelated Reading: PET/MRI ups lesion detection by 15% for some cancers SNMMI 2020: PET/MRI finds location of chronic pain in patients SNMMI 2020: PET/MRI combo tracks osteoarthritis progression PET, MRI uncover women's predisposition to Alzheimer's PET/MRI shows inflammation link to mitral valve prolapse
Source: Headlines - Category: Radiology Source Type: news
Authors: Monreal C, Luinstra L, Larkins L, May J Abstract CONTEXT: Technological advances have given smartphones the capabilities of sensitive clinical measurement equipment at lesser cost and higher availability. The Clinometer is a smartphone application that can be used to measure the joint range of motion in a clinical setting, but psychometric properties of the tool's use measuring cervical range of motion (CROM) are not established. OBJECTIVES: The purpose of this study was to examine the validity and intrarater reliability of the Clinometer application for the measurement of CROM (ie, flexion, exten...
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
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Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
AbstractCholangiocarcinoma (CCA) is the most common malignancy in patients with primary sclerosing cholangitis (PSC) and carries a high rate of mortality. Although the pathogenesis of CCA in PSC is largely unknown, inflammation-driven carcinogenesis concomitant with various genetic and epigenetic abnormalities are underlying factors. The majority of CCA cases develop from a dominant stricture (DS), which is defined as a stricture with a diameter
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
As we heard the history we stopped, prior to hearing the exam and labs, and developed a differential diagnosis.  With the combination of itching, probable jaundice and pale stools we assume either intrahepatic or extrahepatic obstruction.  Our differential diagnosis with commentary:   Primary biliary cirrhosis – much more common in women then men – but does often present at this age with uncontrollable itching Primary sclerosing cholangitis – no history of ulcerative colitis or diarrhea symptoms, but still possible Gallstone – not all common duct stones cause pain Cholangiocarcinoma ...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs
CONCLUSION: Primary sclerosing cholangitis is a rare disease in childhood and adolescence and its initial diagnosis may be de layed or overlooked due to asymptomatic or unspecific clinical manifestations. The association with inflammatory bowel disease is common. Prognosis may be unfavorable as the disease progresses and hepatic transplant is the definitive treatment.RESUMO CONTEXTO: A colangite esclerosante prim ária é uma doença rara, mas sua prevalência tem sido subestimada em crianças e adolescentes, tanto pela variedade de apresentação clínica quanto pela dificuld...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
Question: A 58-year-old woman with a history of ulcerative colitis in clinical remission was referred for endosonographic evaluation of a periduodenal mass. She developed abdominal pain in the right upper quadrant and lost 15 lbs over the preceding 3 months. She denied jaundice. Laboratory studies were remarkable for an elevated alkaline phosphatase (ALP) of>1000 U/L (normal range, 38 –126) without elevation of aminotransferases or bilirubin. She had no history of cholelithiasis or pancreatitis, and no family history of pancreatic cancer.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Clinical Challenges and Images in GI Source Type: research
A 23-year-old woman presented to the emergency department in December, 2016, with a 10-day history of vomiting, myalgia, and upper abdominal pain. 3 days before presentation she had seen her general practitioner who prescribed empirical clarithromycin, with no improvement in her symptoms, and 2 days later she developed jaundice and pruritus, prompting her attendance at our hospital. She had a history of ulcerative colitis with a pan-proctocolectomy and end ileostomy. She took no regular medication, rarely drank alcohol, and had no history of travel abroad or recent blood transfusions.
Source: LANCET - Category: General Medicine Authors: Tags: Case Report Source Type: research
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