The Effect of Adalimumab Treatment on Linear Growth in Children With Crohn Disease: A Post-hoc Analysis of the PAILOT Randomized Control Trial

Objectives: Growth impairment is common in children with Crohn disease (CD). We aimed to assess the effect of adalimumab (ADL) treatment on linear growth in children with CD in a post-hoc analysis of the Pediatric Crohn's Disease AdalImumab Level–based Optimization Treatment randomized controlled trial. Methods: Children 6 to 17 years who responded to ADL induction were assessed consecutively for anthropometric parameters. Associations of these parameters with disease characteristics and disease activity were analyzed. Results: Overall, 66 patients completed 72 weeks of follow-up (25% girls, mean age of 15.6 ± 2.5 years). Median (interquartile range [IQR]) height z score improved from −0.6 (−1.6–0.15) at baseline to −0.33 (−1.3–0.5) at week 72 (P = 0.005) with lesser improvement in patients with perianal disease. Similar effect was noted in children with growth potential (boys younger than 16 years, girls younger than 14 years). Median (IQR) height velocity standard deviation was −0.32 (−1.5–0.8) at week 26, and +0.11 (−1.1–1.3) at week 72. Median weight z score increased from −0.54 (−1.2–0.15) to −0.1 (−0.9–0.6), P 
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Clinical Trials: Gastroenterology: Inflammatory Bowel Disease Source Type: research