Examining what factors mediate treatment effect in chronic low back pain: A mediation analysis of a Cognitive Functional Therapy clinical trial
ConclusionConclusion: CFT did not improve the majority of the hypothesized mediators (stress, fear of physical activity, coping, depression, anxiety and sleep) and these mediators were not associated with either disability or pain. Unfortunately, the proportion of missing data in this study is substantial and these findings can only be considered hypothesis ‐generating. Therefore, future research should examine replicating the results of this study to verify the role of self‐efficacy and other proposed mediators (e.g. stress, coping, sleep, fear) on clinical outcomes.Significance
An exploration of seven potential mediators was undertaken to determine the effect of Cognitive Functional Therapy (CFT) on disability and pain intensity in individuals with chronic low back pain compared to a group exercise and education intervention.
CFT improved pain self ‐efficacy, which was associated with disability and pain outcomes. CFT did not improve the other six potential mediators (stress, fear of physical activity, coping, depression, anxiety and sleep) and these were not associated with disability or pain.
The proportion of missing data in this study i s substantial and these findings should be considered hypothesis‐generating only.
Source: European Journal of Pain - Category: Anesthesiology Authors: Aoife O ’Neill,
Kieran O’Sullivan,
Peter O’Sullivan,
Helen Purtill,
Mary O’Keeffe Tags: ORIGINAL ARTICLE Source Type: research
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