Role of the KCNJ Gene Variants in the Clinical Outcome of Type 1 Diabetes
Horm Metab Res DOI: 10.1055/a-1204-5443Diabetes is considered as a disease with a wide and continuous clinical
spectrum, ranging from Type 1 (T1D) and Type 2 Diabetes (T2D) with complex
multifactorial causes. In the last years, particular attention has been
focused on the predictive value and therapeutic potential of single
nucleotide polymorphisms (SNPs). SNPs can alter the seed-sequence in
miRNA’s loci and miRNA target sites causing changes in the structure
and influencing the binding function. Only few studies have investigated the
clinical influence of SNPs, in particular potassium inwardly rectifying
channel, subfamily J, member 11 (KCNJ) gene variants in T1D population. The
aim of the study is to investigate the occurrence and the possible metabolic
significance of KCNJ polymorphism in a group of pediatric patients with T1D.
The study was performed in a cohort of 90 Caucasian children and adolescents
with T1D and 93 healthy subjects. Rs5210 polymorphism has been analyzed with
a prevalence of the GG genotype in the patient group suggesting its
association with T1D. Therefore, a relationship was found between GG
genotype and body mass index (BMI) at diagnosis and insulin requirement (IR)
after 6 months. The study suggested an action for rs5210 in determining the
metabol...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Blasetti, Annalisa Castorani, Valeria Comegna, Laura Franchini, Simone Prezioso, Giovanni Provenzano, Martina Di Giulio, Concetta Iannucci, Daniela Matonti, Lorena Tumini, Stefano Chiarelli, Francesco Stuppia, Liborio Tags: Endocrine Care Source Type: research
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