Glaucoma after ocular surgery or trauma: the role of infiltrating monocytes and their response to cytokine inhibitors.

Glaucoma is a frequent and devastating long-term complication following ocular trauma, including corneal surgery, open globe injury, chemical burn, infection, etc. Post-event inflammation and neuroglial remodeling plays a key role in subsequent ganglion cell apoptosis and glaucoma. To this end, this study was designed to investigate the amplifying role of monocyte infiltration into the retina. By using 3 different ocular injury mouse models (corneal suture, penetrating keratoplasty, and globe injury) and monocyte fate mapping techniques we show that ocular trauma or surgery can cause robust infiltration of bone marrow-derived monocytes into the retina and subsequent neuroinflammation by upregulation of TNF- α, IL-1β and IL-6 mRNA within 24 hours.

Source: American Journal of Pathology - July 17, 2020 Category: Pathology Authors: Xiaoniao Chen, Fengyang Lei, Chengxin Zhou, James Chodosh, Liqiang Wang, Yifei Huang, Claes H. Dohlman, Eleftherios I. Paschalis Source Type: research