Viruses, Vol. 12, Pages 762: Cocirculation of Swine H1N1 Influenza A Virus Lineages in Germany

Viruses, Vol. 12, Pages 762: Cocirculation of Swine H1N1 Influenza A Virus Lineages in Germany Viruses doi: 10.3390/v12070762 Authors: Zell Groth Krumhbolz Lange Philipps Dürrwald The genome analysis of 328 H1N1 swine influenza virus isolates collected in a 13-year long-term swine influenza surveillance in Germany is reported. Viral genomes were sequenced with the Illumina next-generation sequencing technique and conventional Sanger methods. Phylogenetic analyses were conducted with Bayesian tree inference. The results indicate continued prevalence of Eurasian avian swine H1N1 but also emergence of a novel H1N1 reassortant, named Schneiderkrug/2013-like swine H1N1, with human-like hemagglutinin and avian-like neuraminidase and internal genes. Additionally, the evolution of an antigenic drift variant of A (H1N1) pdm09 was observed, named Wachtum/2014-like swine H1N1. Both variants were first isolated in northwest Germany, spread to neighboring German states and reached greater proportions of the H1N1 isolates of 2014 and 2015. The upsurge of Wachtum/2014-like swine H1N1 is of interest as this is the first documented persistent swine-to-swine spread of A (H1N1) pdm09 in Germany associated with antigenic variation. Present enzootic swine influenza viruses in Germany now include two or more co-circulating, antigenically variant viruses of each of the subtypes, H1N1 and H1N2.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research

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In conclusion, it is necessary for the well-being of humans and pigs to closely monitor swine influenza viruses containing avian-like hemagglutinin with PA and NP genes from 2009 pandemic H1N1 influenza viruses.
Source: Archives of Virology - Category: Virology Source Type: research
This study reports virological and epidemiological data accumulated through passive surveillance conducted during 1,825 herd visits from 2011 to 2018. Among them, 887 (48.6%) tested swIAV-positive. The proportion of positive cases remained stable year-on-year and year-round. The European avian-like swine H1N1 (H1avN1) virus was the most frequently identified (69.6%), and was widespread across the country. The European human-like reassortant swine H1N2 (H1huN2) virus accounted for 22.1% and was only identified in the north-western quarter and recently in the far north. The 2009 pandemic H1N1 (H1N1pdm) virus (3.6%) was detec...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Source: European Union, European Centre for Disease Prevention and Control (ECDC). Published: 2019. This five-page report is based on data on zoonotic influenza for 2017 retrieved from Epidemic Intelligence on May 18, 2018. No human cases of avian influenza were reported in the European Union/European Economic Area. Sporadic cases were reported from Africa and Asia. Influenza viruses A(H1N1)v, A(H1N2)v, and A(H3N2)v of swine origin caused human cases in Switzerland and the United States. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Source: European Union, European Centre for Disease Prevention and Control (ECDC). Published: 2019. This five-page report is based on data on zoonotic influenza for 2017 retrieved from Epidemic Intelligence on May 18, 2018. No human cases of avian influenza were reported in the European Union/European Economic Area. Sporadic cases were reported from Africa and Asia. Influenza viruses A(H1N1)v, A(H1N2)v, and A(H3N2)v of swine origin caused human cases in Switzerland and the United States. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
AbstractPurpose of ReviewZoonotic influenza viruses are those that cross the animal-human barrier and can cause disease in humans, manifesting from minor respiratory illnesses to multiorgan dysfunction. They have also been implicated in the causation of deadly pandemics in recent history. The increasing incidence of infections caused by these viruses worldwide has necessitated focused attention to improve both diagnostic as well as treatment modalities. In this first part of a two-part review, we describe the structure of zoonotic influenza viruses, the relationship between mutation and pandemic capacity, pathogenesis of i...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
Isolation of a Reassortant H1N2 Swine Flu Strain of Type "Swine-Human-Avian" and Its Genetic Variability Analysis. Biomed Res Int. 2018;2018:1096079 Authors: Wang LB, Chen QY, Wu XM, Che YL, Wang CY, Chen RJ, Zhou LJ Abstract We isolated an influenza strain named A/Swine/Fujian/F1/2010 (H1N2) from a pig suspected to be infected with swine flu. The results of electron microscopy, hemagglutination (HA) assay, hemagglutination inhibition (HI) assay, and whole genome sequencing analysis suggest that it was a reassortant virus of swine (H1N1 subtype), human (H3N2 subtype), and avian influenza vir...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: 1 September 2018Source: Preventive Veterinary Medicine, Volume 157Author(s): Sébastien Grech-Angelini, Séverine Hervé, Nicolas Rose, Nicolas Barbier, François Casabianca, Oscar Maestrini, Alessandra Falchi, Gaëlle SimonAbstractCorsica is a mountainous French island in the north-western Mediterranean Sea. It is a rural area, where pig farming is a major economic activity. Although no acute respiratory outbreaks due to swine influenza A viruses (swIAVs) have ever been reported in this free-ranging pig breeding system, influenza A viruses (IAVs) could be circulating within th...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Summary Three subtypes—H1N1, H1N2 and H3N2—of influenza A viruses of swine (IAVs‐S) are currently endemic in swine worldwide, but there is considerable genotypic diversity among each subtype and limited geographical distribution. Through IAVs‐S monitoring in Vietnam, two H1N2 influenza A viruses were isolated from healthy pigs in Ba Ria‐Vung Tau Province, Southern Vietnam, on 2 December 2016. BLAST and phylogenetic analyses revealed that their HA and NA genes were derived from those of European avian‐like H1N2 IAVs‐S that contained avian‐origin H1 and human‐like N2 genes, and were particularly clo...
Source: Transboundary and Emerging Diseases - Category: Veterinary Research Authors: Tags: SHORT COMMUNICATION Source Type: research
This study investigated the prevalence of IAV in commercial swine herds. A total of 1,878 oral fluid samples were collected from pigs of all ages from 201 commercial farms located in North Carolina and South Carolina. Sixty-eight oral fluid samples from 35 farms were positive by MP gene PCR with an overall IAV-positivity of 3.6%. On the herd level, the percentage of IAV positivity was 17.4%. Fifty-six viruses were subtyped, while 12 were partly subtyped or not subtyped at all. Using de novo assembly, complete sequences were obtained for 59 HA genes. The majority of IAVs subtyped had an H1 HA demonstrating a considerable pr...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 7 September 2016 Source:Veterinary Microbiology Author(s): Maria Serena Beato, Luca Tassoni, Adelaide Milani, Annalisa Salviato, Guido Di Martino, Monica Mion, Lebana Bonfanti, Isabella Monne, Simon James Watson, Alice Fusaro In August 2012 repeated respiratory outbreaks caused by swine influenza A virus (swIAV) were registered for a whole year in a breeding farm in northeast Italy that supplied piglets for fattening. The virus, initially characterized in the farm, was a reassortant Eurasian avian-like H1N1 (H1avN1) genotype, containing a haemagglutinin segment derived from the pandemic ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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