LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors [Medical Sciences]

LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of either wild-type (WT) LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increases the penetrance of MYCN-induced neuroblastoma, potentiates the invasion and...

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Ting Tao, Hui Shi, Luca Mariani, Brian J. Abraham, Adam D. Durbin, Mark W. Zimmerman, John T. Powers, Pavlos Missios, Kenneth N. Ross, Antonio R. Perez-Atayde, Martha L. Bulyk, Richard A. Young, George Q. Daley, A. Thomas Look Tags: Biological Sciences Source Type: research