Sex is associated with differences in gut microbial composition and function in hepatic encephalopathy

Patients with liver cirrhosis develop changes in their brain function, and men often develop feminization with disease progression. However, the interaction between sex, microbiota and disease severity is unclear. We found that as disease progressed, microbiota in men that were different from women approached their composition with changes in specific microbes that are associated with male hormone metabolism.

Source: Journal of Hepatology - July 12, 2020 Category: Gastroenterology Authors: Krishnakant Saboo, Amirhossein Shamsaddini, Mihir V. Iyer, Chang Hu, Andrew Fagan, Edith A. Gavis, Melanie B. White, Michael Fuchs, Douglas M. Heuman, Masoumeh Sikaroodi, Ravishankar K. Iyer, Patrick M. Gillevet, Jasmohan S. Bajaj Source Type: research