Synthesis and Excretion of Atrial Natriuretic Peptide in Secretory Cardiomyocytes in Experimental Hypertension

The intensity of accumulation and excretion of atrial natriuretic peptide in myocytes of the right atrium in rat models of renovascular hypertension and salt loading was studied by immunocytochemical analysis and transmission electron microscopy. The data suggest that high BP is not the decisive factor affecting secretion of atrial natriuretic peptide in atrial cardiomyocytes. The regulatory mechanisms of the accumulation and release of the peptide from myocyte granules can vary and depend on the pathogenesis of hypertension.
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research