Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation

In conclusion, deguelin is a potent in vitro inhibitor of the mutant form of NPM1, which provides the molecular basis for its anti-leukemia activities in NPM1 mutant acute myeloid leukemia cells.

http://link.springer.com/10.1007/s00277-014-2206-x

Source: Annals of Hematology - January 13, 2015 Category: Hematology Source Type: research