Biopharmaceutics and Pharmacokinetics of Timosaponin A-III by a Sensitive HPLC-MS/MS Method: Low Bioavailability Resulting from Poor Permeability and Solubility.

Conclusion: nistration, which was probably caused by its low permeability and solubility. This study may provide a reference for the rational clinical use and further study on the pharmacology or toxicology of timosaponin A-III.
PMID: 32634081 [PubMed - as supplied by publisher]

Source: Current Pharmaceutical Biotechnology - July 6, 2020 Category: Biotechnology Authors: Wang HQ, Gong XM, Lan F, Zhang YH, Xia JE, Wang L, Zhang H, Liu M Tags: Curr Pharm Biotechnol Source Type: research