Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated Factors

ConclusionThe PK of MgSO4 in pregnant women with PE is significantly affected by creatinine and body weight. Pregnant women with PE and higher body weight have a higherV and, consequently, a lower elimination rate of MgSO4. Pregnant women with PE and a higher serum creatinine value show lower CL and, therefore, lower MgSO4 elimination rate.

http://link.springer.com/10.1007/s40268-020-00315-2

Source: Drugs in R&D - July 7, 2020 Category: Drugs & Pharmacology Source Type: research