Recombinant Proteins Of A Pakistani Strain Of Hepatitis E And Their Use In Diagnostic Methods And Vaccines

A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.IC: NIAIDNIH Ref. No.: E-141-1992-2TAB No: TAB-328Provider Technology ID: 328Updated On: Jul 6, 2020Date Published: Monday, July 6, 2020Patent Application: 08/809,52309/724,47509/724,452Patent Authority: USUSEIRUSPatent Number: 6,207,4166,787,145Lead Inventor: Inventor IC: NIAIDNIAIDNIAIDLPM FIrst Name: PeterLPM Last Name: SoukasLPM Address: 5601 Fishers Lane, Suite 6D (MSC 9804)LPM City: RockvilleLPM Zip: 20892-9804Inv Is lead: LPM State: MDLPM Phone: [phone]LPM Email: [e-mail] Suffix: J.D.LPM Organization: NIH Office of Technology TransferLPM Fax: [phone]DTDT Classification: Infectious DiseasesDiagnosticsNon-AIDS (only)VaccinesNon-AIDS (only)DTDT Description: Infectious DiseasesInfectious Diseases - DiagnosticsInfectious Diseases - Diagnostics - Viral: Non-AIDSInfectious Diseases - VaccinesInfectious Diseases ...

Source: NIH OTT Licensing Opportunities - July 6, 2020 Category: Research Authors: ott-admin Source Type: research