Relationship Between Hematoma Expansion Induced by Hypertension and Hyperglycemia and Blood –brain Barrier Disruption in Mice and Its Possible Mechanism: Role of Aquaporin-4 and Connexin43

In conclusion, the optimized HE model is induced by hypertension and hyperglycemia with the criterion of hematoma volume expanding ≥ 45.0%. HH-HE leads to BBB disruption, which is dependent on AQP4 and Cx43.
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research