Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death

Conclusions: Our findings suggested that PRMT6 might serve as a new therapeutic target to prevent hearing loss caused by aminoglycoside- and cisplatin-induced ototoxicity by preventing ROS formation and modulating the mitochondria-related damage and apoptosis.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yingzi He, Wen Li, Zhiwei Zheng, Liping Zhao, Wenyan Li, Yunfeng Wang, Huawei Li Tags: Research Paper Source Type: research