Death Domain-Associated Protein Promotes Colon Cancer Metastasis through Direct Interaction with ZEB1

Conclusion: In sum, these findings supported that the loss of DAXX is associated with cancer cell metastases in CRC. ZEB1-mediated transcriptional suppression of E-cadherin is a possible mechanism. DAXX/ZEB-1 pathway could be a potential therapeutic target for preventing cancer metastasis in CRC.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yanliang Liu, Fengqin Guo, Xu Zhu, Wenyi Guo, Tao Fu, Weixing Wang Tags: Research Paper Source Type: research