Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF- κB pathway

Emerging evidence suggests an association of Alzheimer's Disease (AD) with microglial and astrocytic dysregulation. Recent studies have proposed thatactivated microglia can transform astrocytes to a neurotoxic A1 phenotype, which has been shown to be involved in the promotion of neuronal damage in severalneurodegenerative diseases, including AD. In the present study, we observed anobvious microglial activation and A1-specific astrocyte response in the brain tissue of APP/PS1 Tg mice. Fasudil treatment improved the cognitive deficits of APP/PS1 Tg mice, inhibited microglial activation and promoted their transformation to ananti-inflammatory phenotype, and further shiftedastrocytes from an A1 to an A2phenotype.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research