Cumulative effects of ciprofloxacin and pilocarpine on cytotoxicity and G0 phase arrest in hepatoma ‐derived Hep G2 cell line

ConclusionsCiprofloxacin imposed mitochondrial ‐independent apoptosis while PILO + CPF caused mitochondrial‐dependent and independent apoptosis simultaneously. Consequently, coadministration of PILO and CPF causes intense cytotoxic effects through targeting the mitochondria, DNA gyrase enzyme and other unknown mechanisms.

Source: Journal of Pharmacy and Pharmacology - June 20, 2020 Category: Drugs & Pharmacology Authors: Leila Sadeghi, Somaiyeh Maleki, Gholamreza Dehghan Tags: Research Paper Source Type: research