Putting the 2019 CLAD Consensus Definitions to the Test: Two Steps Forward, One Step Back?

Since the inception of lung transplantation, serial pulmonary function testing (PFT) has been key to quantifying allograft health. In 1993 an International Society for Heart and Lung Transplantation (ISHLT) consensus report standardized the approach to using PFT measures to benchmark lung allograft function1. Specifically chronic graft dysfunction, or bronchiolitis obliterans syndrome (BOS), was suggested by a sustained ≥20% decline in forced expiratory volume in 1 second (FEV1) as compared to the average of the two best posttransplant FEV1s measured at least three weeks apart in the absence of evident confounders1.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research