NMDA receptor modulates spinal iron accumulation via activating DMT1(-)IRE in remifentanil-induced hyperalgesia

Mounting data from animal and observational human studies are raising the concern that opioids, commonly used to supply sufficient analgesia in general anesthesia, may cause paradoxical pain amplification after their exposure which is called opioid-induced hyperalgesia (OIH).3,4,10,20,32 In particular, the phenomenon of hyperalgesia is responsible for weakening antinociception from sustained medication, thereby leading to irritable allodynia and supplemental drug consumption.3 The μ-opioid receptor agonist remifentanil is an important component in clinical anesthesia, while it is definitely inclined to induce hyperalgesia compared to other opioids.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research