Left-Ventricular Function After 3  Months of Sacubitril-Valsartan in Acute Decompensated Heart Failure

AbstractThere is limited data on the effect of sacubitril-valsartan on the echocardiographic parameters in acute decompensated heart failure (ADHF). We prospectively enrolled 68 consecutive patients with ADHF who received sacubitril-valsartan (N = 34, S/V group) or angiotensin inhibition-based therapy (N = 34, ACEi/ARB group). Two-dimensional echocardiography with speckle tracking (2D-STE) was performed at baseline and after 3 months of treatment. Changes in 2D-STE parameters, including global longitudinal strain (GLS), were compared between the groups byt test and ANCOVA. Baseline characteristics were similar between the groups. Following 3  months of treatment, LVEF and GLS significantly improved in the S/V group (mean LVEF from 27 to 34.5% and GLS from − 6.6 to − 9.4%) but not in ACEi/ARB group. The improvement in LVEF and GLS was more prominent in patients with non-ischemic cardiomyopathy. In patients with ADHF 3-month trea tment with sacubitril-valsartan, compared to guideline directed medical therapy without sacubitril, improves LVEF and GLS.Graphical AbstractA typical change in GLS in a patient with acute decompensated heart failure after 3 months of sacubitril-valsartan
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research