LB965 Follicular trochanters: A potential mechanism for stem cell depletion in scarring alopecia

The follicular bulge is a stem cell niche where the outer root sheath (ORS) abuts the arrector pili muscle insertion site in both murine and human hair follicles. Prior studies have recognized an uncommon structure termed the “follicular trochanter” which was described as an epithelial protrusion of the outer root sheath in anagen follicles. It has been shown that these structures prominently express keratin 15, a stem cell marker. We sought to determine if trochanters embedded in the fibrotic stroma contribute to fo llicular scarring in cicatricial alopecias.

Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: F.C. Roche, A. Fischer, K.J. Gaddis, T. Dentchev, S.C. Taylor, J.T. Seykora Tags: Skin, Appendages, and Stem Cell Biology Source Type: research