Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR ‐143‐3p/TGF‐β1 axis
ConclusionsOur studies demonstrated that the protective effect of MET on DN was attributed to the inhibition of proliferation, inflammation and ECM accumulation in mesangial cells via H19/miR ‐143‐3p/TGF‐β1 axis, which suggested that the H19/miR‐143‐3p/TGF‐β1 axis could be a valuable target for DN therapies.
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Jiang Xu,
Ping Xiang,
Linqing Liu,
Jianran Sun,
Shandong Ye Tags: Research Paper Source Type: research
More News: Diabetes | Drugs & Pharmacology | Endocrinology | Fortamet | Genetics | Metformin | Study