Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease.
Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease. Eur J Endocrinol. 2020 Jul;183(1):73-81 Authors: Fichna M, Małecki PP, Młodzikowska M, Gębarski B, Ruchała M, Fichna P Abstract Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD. Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. The control group comprised 143 age-matched volunteers. Results: Autoimmune diseases were diagnosed in 38.1% relatives. Hashimoto's thyroiditis was found in 20.3%, Graves' disease in 8.0%, vitiligo and type 1 diabetes in 3.5%, whereas AD, rheumatoid arthritis and atrophic gastritis with pernicious anaemia in 2.7% each. All studied antibodies except for islet antigen-2 (P = 0.085) were significantly more frequent in AD relatives than in controls (P
Publication date: Available online 25 September 2020Source: Materials Today: ProceedingsAuthor(s): A. Emi Princess Prasanna, P. Karpagavinayagam, Saminathan Kulandaivel, C.Vedhi
We present a critical discussion in which a chronic state of systemic proinflammation sustained over the course of several decades and engendered by ongoing metabolic or autoimmune disease is predicted to promote severe disruptions of central neurological processes. Specifically, long-term functional rundown of microglial-mediated phagocytic activity in concert with aberrant expression and cellular deposition of beta amyloid and tau protein facilitates formation of senile plaques and neurofibrillary tangles. Within this functional context, we hypothesize that early initiation events in the pathophysiology of AD may operati...
Abstract Fatigue associated with arthritis is highly prevalent and interferes with patients' daily routines. An interdisciplinary research team developed the Tablet-based Cognitive Behavioral Intervention (Tab-CBI) for older adults with arthritis fatigue. The goal of the Tab-CBI is to alleviate fatigue by promoting a simple walking activity. The Tab-CBI application used off-the-shelf technologies and was implemented on a mini-tablet computer. The four key components of Tab-CBI are: (a) multimedia cognitive-behavioral therapy (CBT)-based educational modules; (b) videoconferencing communication; (c) individualized g...
Authors: Atal MK, Palei SK, Chaudhary DK, Kumar V, Karmakar NC Abstract Whole-body vibration (WBV) is one of the leading risk factors for the development of musculoskeletal disorder (MSD) that develops symptoms of lower back pain, pain in neck and shoulders, digestive problems, blood pressure and diabetes among professional dumper operators. The present study is specifically aimed at assessing the WBV exposure of 79 dumper operators engaged in two Indian opencast coal mines through vibration measurements followed by questionnaire survey. From daily frequency-weighted rms exposure A(8), it is found that dumper opera...
Publication date: 15 February 2021Source: Journal of Alloys and Compounds, Volume 854Author(s): Ki-Wook Sung, Bon-Ryul Koo, Hyo-Jin Ahn
Publication date: Available online 25 September 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Wang Deng, Jianing Xu, Jihui Wang, Wenbin Hu
CONCLUSIONS: The factors associated with hypertension awareness, treatment, and control were different by sex and age group. Enhancing attention on hypertension among young hypertension and encouraging them to visit clinics would be key strategies to improve hypertension management among the young hypertensive population. PMID: 32975054 [PubMed - as supplied by publisher]
CONCLUSION: Right ventricular pressure overload in APE has an effect on f(QRS-T). In thrombolytic treatment, the change of f(QRS-T) angle may be a marker of successful thrombolysis. PMID: 32975629 [PubMed - as supplied by publisher]
Publication date: September–October 2020Source: Reumatología Clínica (English Edition), Volume 16, Issue 5, Part 2Author(s): Yasser Emad, Yasser Ragab, Magdy Abd-Elsalam, Johannes J. Rasker
Publication date: September–October 2020Source: Reumatología Clínica (English Edition), Volume 16, Issue 5, Part 2Author(s): Ángeles Acosta-Mérida, Antonio Naranjo, Carlos Rodríguez-Lozano