Crocin Reverses Depression-Like Behavior in Parkinson Disease Mice via VTA-mPFC Pathway

In conclusion, our study demonstrated that crocin protected the DA projection neurons in the VTA through activating mTOR, which subsequentl y improved the neural synaptic plasticity of mPFC, and ameliorated depression-like behavior in PD mice.
Source: Molecular Neurobiology - Category: Neurology Source Type: research