Primary Aldosteronism and Obstructive Sleep Apnea: Casual Association or Pathophysiological Link?
Horm Metab Res DOI: 10.1055/a-1133-7255The coexistence of aldosterone oversecretion and obstructive sleep apnea is
frequently observed, especially in patients with resistant hypertension,
obesity, and metabolic syndrome. Since aldosterone excess and sleep apnea are
both independently associated with an increased risk of cardiovascular disease,
to investigate whether their coexistence might be attributed to common
predisposing conditions, such as metabolic disorders, or to an actual
pathophysiological interconnection appears of great importance. Fluid overload
and metabolic abnormalities relating to aldosterone oversecretion may be
implicated in obstructive sleep apnea development. Nocturnal intermittent
hypoxia may in turn exacerbate renin-angiotensin-aldosterone system activity,
thus leading to hyperaldosteronism. Furthermore, fat tissue excess and adipocyte
secretory products might predispose to both sleep apnea and aldosterone
oversecretion in subjects with obesity. Consistent with these evidences,
obstructive sleep apnea frequently affects patients with primary aldosteronism.
Conversely, whether primary aldosteronism is more prevalent in individuals
affected by obstructive sleep apnea compared to the general population remains
controversial. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJo...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Pecori, Alessio Buffolo, Fabrizio Pieroni, Jacopo Forestiero, Vittorio Sconfienza, Elisa Veglio, Franco Mulatero, Paolo Monticone, Silvia Tags: Review Source Type: research
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