Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency.

CONCLUSIONS: Longitudinal analysis confirms an EPA phenotype characterized by features of metabolic dysfunction. Blood measures of IL-6, but not eosinophils, were significantly associated with EPA, and IL-6 and eosinophils predicted exacerbations in the sample as a whole.
PMID: 32479111 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory and Critical Care Medicine - May 31, 2020 Category: Respiratory Medicine Authors: Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, Israel E, Levy BD, Phipatanakul W, Jarjour NN, Castro M, Wenzel SE, Hastie A, Moore W, Bleecker E, Fahy JV, Denlinger LC, National Heart Lung and Blood Institute Severe Asthma Research Program Tags: Am J Respir Crit Care Med Source Type: research