Specific single nucleotide polymorphism genotypes and association of an IL-12B polymorphism with secondary failure of infliximab therapy in Japanese psoriasis patients

Genome-wide association studies have demonstrated associations between susceptibility to psoriasis and single nucleotide polymorphisms (SNPs). Part of the genetic susceptibility can be explained by the established susceptibility locus in the human leukocyte antigen complex on chromosome 6p21.3, as well as polymorphisms at the interleukin 12B (IL-12B), IL-23A, IL-23 receptor (IL-23R), tumor necrosis factor-a induced protein 3 (TNFAIP3), and TNIP1 (TNFAIP3 interacting protein 1) loci [1 –5]. Investigating susceptibility loci in patients with psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) may help to determine whether the skin lesions result from a common genetic background.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research