Association of a Type 2 –Polarized T Cell Phenotype With Methotrexate Nonresponse in Patients With Rheumatoid Arthritis

ConclusionWe observed a bias toward type 2 –polarized T cell inflammatory responses in the peripheral blood of MTX ‐nonresponsive RA patients. Targeting the IL ‐13+CD 4+ T cell pathway could be a new therapeutic strategy in RA patients whose disease remains resistant to MTX .

Source: Arthritis and Rheumatology - May 28, 2020 Category: Rheumatology Authors: Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Anik ó Malik, Ian D. Haidl, Jean S. Marshall, Thomas B. Issekutz Tags: Original Article Source Type: research