Post-translational Modifications of Opioid Receptors.

Post-translational Modifications of Opioid Receptors.
Trends Neurosci. 2020 Jun;43(6):417-432
Authors: Lemos Duarte M, Devi LA
Abstract
Post-translational modifications (PTMs) are key events in signal transduction since they affect protein function by regulating their abundance and/or activity. PTMs involve the covalent attachment of functional groups to specific amino acids. Since they tend to be generally reversible, PTMs serve as regulators of signal transduction pathways. G-protein-coupled receptors (GPCRs) are major signaling proteins that undergo multiple types of PTMs. In this Review, we focus on the opioid receptors, members of GPCR family A, and highlight recent advances in the field that have underscored the importance of PTMs in the functional regulation of these receptors. Since opioid receptor activity plays a central role in the development of tolerance and addiction to morphine and other drugs of abuse, understanding the molecular mechanisms regulating receptor activity is of fundamental importance.
PMID: 32459993 [PubMed - in process]

Source: Trends in Neurosciences - May 29, 2020 Category: Neuroscience Authors: Lemos Duarte M, Devi LA Tags: Trends Neurosci Source Type: research