Alterations in Pancreatic Islet Cell Function in Response to Small Bowel Resection.
Conclusion Following massive SBR, there is significant hypertrophy of pancreatic islet cells with morphologically intact a- and b-cells. Significantly reduced pancreatic insulin release in both static and dynamic conditions demonstrate perturbed intrinsic b-cell function. GLP-1 is a key mediator of this amplification pathway. Decreased expression of serum GLP-1 and pancreatic GLP-1R in face of no change in insulin content offer a novel pathway for enteropancreatic glucose regulation following SBR.
PMID: 32463335 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - Category: Physiology Authors: Courtney CM, Shyr ZA, Yan Z, Onufer EJ, Steinberger AE, Tecos ME, Barron LK, Guo J, Remedi MS, Warner BW Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
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