Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19.
Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19.
Cell Host Microbe. 2020 May 27;:
Authors: Park A, Iwasaki A
Abstract
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics or vaccines to this ongoing global threat, type I and type III interferons (IFNs) are currently being evaluated for their efficacy. Both the role of IFNs and the use of recombinant IFNs in two related, highly pathogenic coronaviruses, SARS-CoV and MERS-CoV, have been controversial in terms of their protective effects in the host. In this review, we describe the recent progress in our understanding of both type I and type III IFN-mediated innate antiviral responses against human coronaviruses and discuss the potential use of IFNs as a treatment strategy for COVID-19.
PMID: 32464097 [PubMed - as supplied by publisher]
Source: Cell Host and Microbe - Category: Microbiology Authors: Park A, Iwasaki A Tags: Cell Host Microbe Source Type: research
More News: Coronavirus | COVID-19 | MERS | Microbiology | Pandemics | Respiratory Medicine | SARS | Vaccines