nAnnexin A1 is a Potential Novel Biomarker of Congestion in Acute Heart Failure

Objectives: The study sought to identify the role of Annexin A1 as a congestion marker in acute heart failure, and to identify its putative role in predicting clinical outcomes.Background: Annexin A1 (AnxA1) is a protein that inhibits inflammation following ischemia-reperfusion (I-R) injury in cardiorenal tissues. Since acute heart failure (AHF) is a state of tissue hypoperfusion, we hypothesized that plasma AnxA1 levels are altered in AHF.Methods: In The Renal Optimization Strategies Evaluation (ROSE) trial, patients hospitalized for AHF with kidney injury were randomized to receive dopamine, nesiritide, or placebo for 72 hours in addition to diuresis.

Source: Journal of Cardiac Failure - May 27, 2020 Category: Cardiology Authors: Fadi W. Adel, Aruna Rikhi, Siu-Hin Wan, Seethalakshmi R. Iyer, Hrishikesh Chakraborty, Steven McNulty, W.H. Wilson Tang, G. Michael Felker, Michael M. Givertz, Horng H Chen Source Type: research