Common and dissociable effects of oxytocin and lorazepam on the neurocircuitry of fear [Neuroscience]

Benzodiazepines (BZDs) represent the gold standard of anxiolytic pharmacotherapy; however, their clinical benefit is limited by side effects and addictive potential. Consequently, there is an urgent need to develop novel and safe anxiolytics. The peptide hormone oxytocin (OXT) exhibits anxiolytic-like properties in animals and humans, but whether OXT and BZDs...

Source: Proceedings of the National Academy of Sciences - May 25, 2020 Category: Science Authors: Ann–Kathrin Kreuder, Dirk Scheele, Johannes Schultz, Juergen Hennig, Nina Marsh, Torge Dellert, Ulrich Ettinger, Alexandra Philipsen, Mari Babasiz, Angela Herscheid, Laura Remmersmann, Ruediger Stirnberg, Tony Stocker, Rene Hurlemann Tags: Biological Sciences Source Type: research