Cancers, Vol. 12, Pages 1358: Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis
Cancers, Vol. 12, Pages 1358: Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis
Cancers doi: 10.3390/cancers12061358
Authors:
Mette Lorenzen
John Erik Nielsen
Christine Hjorth Andreassen
Anders Juul
Birgitte Grønkær Toft
Ewa Rajpert-De Meyts
Gedske Daugaard
Martin Blomberg Jensen
Luteinizing hormone/choriogonadotropin receptor (LHCGR) regulates gonadal testosterone production and recent studies have suggested a growth-regulatory role in somatic cancers. Here, we established that LHCGR is expressed in a fraction of seminoma cells and germ cell neoplasia in situ (GCNIS), and the seminoma-derived cell line TCam2 released LHCGR into the medium. LH treatment induced proliferation of TCam2 cells in vitro, while hCG treatment induced a non-significant 51% increase in volume of tumors formed in a TCam2 xenograft model. A specific ELISA was used to detect a soluble LHCGR in serum. Serum concentrations of soluble LHCGR could not distinguish 4 patients with GCNIS and 216 patients with testicular germ cell tumors (TGCTs) from 297 infertile or 148 healthy young men. Instead, serum LHCGR levels were significantly higher in 112 patients with a seminoma > 5 cm or elevated serum lactate dehydrogenase (LDH) compared with men harboring smaller seminomas < 2 cm or normal LDH levels. Serum LHCGR levels in TGCT patients could not predict relapse irrespective whether determined...
Source: Cancers - Category: Cancer & Oncology Authors: Mette Lorenzen John Erik Nielsen Christine Hjorth Andreassen Anders Juul Birgitte Gr ønkær Toft Ewa Rajpert-De Meyts Gedske Daugaard Martin Blomberg Jensen Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Germ Cell Tumors | Hormones | Infertility | Reproduction Medicine | Seminoma | Study | Testicular Cancer