The immune suppressive factors CD155 and PD-L1 show contrasting expression patterns and immune correlates in ovarian and other cancers.

CONCLUSIONS: CD155 and PD-L1 exhibit contrasting expression patterns, TIL associations and prognostic significance, suggesting they represent non-redundant immunosuppressive mechanisms. The CD155/TIGIT pathway represents a compelling immunotherapeutic target for HGSC and for immunologically cold tumors in general. PMID: 32446718 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32446718?dopt=Abstract

Source: Gynecologic Oncology - May 19, 2020 Category: Cancer & Oncology Authors: Smazynski J, Hamilton PT, Thornton S, Milne K, Wouters MCA, Webb JR, Nelson BH Tags: Gynecol Oncol Source Type: research