Author's reply to: Arterial stiffness improvement after adding on PCSK9 inhibitors in patients with familial hypercholesterolemia, a letter from Papaioannou and colleagues

We are very grateful to Papaioannou and his team for opening the interesting question about the potential link between lipid factors control, vascular and endothelial damage, pulse wave velocity (PWV), and cardiovascular (CV) risk.1 Low-density lipoprotein cholesterol (LDL-C) and blood pressure are indeed two of the most important CV risk factors, and low variability of LDL-C and systolic blood pressure are associated with a significant reduction of CV events.2 As they already underlined, we found that by reducing LDL-C with optimal lipid-lowering therapy, adding on ezetimibe and eventually PCSK9 inhibitor to highly effective statin, PWV profile may significantly improve in subjects with familial hypercholesterolemia.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Letter to the Editor Source Type: research