Proteomic Applications in Pathology and Laboratory Medicine: Present State and Future Prospects.

Proteomic Applications in Pathology and Laboratory Medicine: Present State and Future Prospects.
Clin Biochem. 2020 May 19;:
Authors: Holmes DT, Romney MG, Angel P, DeMarco ML
Abstract
Clinical mass spectrometry applications have traditionally focused on small molecules, particularly in the areas of therapeutic drug monitoring, toxicology, and measurement of endogenous and exogenous steroids. More recently, the use of matrix assisted laser desorption/ionization time of flight mass spectrometry for the identification of microbial pathogens has been widely implemented. Following this evolution, there has been an expanding role for the measurement of peptides and proteins in pathology and laboratory medicine. This review explores the current state of protein measurement by clinical mass spectrometry and the analytical strategies employed, as well as emerging applications in clinical chemistry, clinical microbiology and anatomical pathology.
PMID: 32442429 [PubMed - as supplied by publisher]

Source: Clinical Biochemistry - May 18, 2020 Category: Biochemistry Authors: Holmes DT, Romney MG, Angel P, DeMarco ML Tags: Clin Biochem Source Type: research