ADH1B*2 is Associated With Reduced Severity of Nonalcoholic Fatty Liver Disease in Adults, Independent of Alcohol Consumption

Alcohol dehydrogenase 1B (ADH1B) is involved in alcohol metabolism. The allele A (ADH1B*2) of rs1229984: A>G variant in ADH1B is associated a higher alcohol metabolizing activity, compared to the ancestral allele G (ADH1B*1). Moderate alcohol consumption is associated with reduced severity of nonalcoholic fatty liver disease (NAFLD), based on histologic analysis, compared with no alcohol consumption. However, it is unclear whether ADH1B*2 modifies the relationship between moderate alcohol consumption and severity of NAFLD.

Source: Gastroenterology - May 21, 2020 Category: Gastroenterology Authors: Vilar-Gomez Eduardo, Sookoian Silvia, Pirola Carlos Jose, Liang Tiebing, Gawrieh Samer, Cummings Oscar, Liu Wanqing, Chalasani Naga Source Type: research