Positive epistasis between viral polymerase and the 3' untranslated region of its genome reveals the epidemiologic fitness of dengue virus [Microbiology]

Dengue virus (DENV) is a global health threat, causing repeated epidemics throughout the tropical world. While low herd immunity levels to any one of the four antigenic types of DENV predispose populations to outbreaks, viral genetic determinants that confer greater fitness for epidemic spread is an important but poorly understood...

Source: Proceedings of the National Academy of Sciences - May 18, 2020 Category: Science Authors: Ayesa Syenina, Dhanasekaran Vijaykrishna, Esther Shuyi Gan, Hwee Cheng Tan, Milly M. Choy, Tanamas Siriphanitchakorn, Colin Cheng, Subhash G. Vasudevan, Eng Eong Ooi Tags: Biological Sciences Source Type: research