Differential mechanisms of tolerance induced by NMDA and 3,5 ‐dihydroxyphenylglycine (DHPG) preconditioning

In conclusion, preconditioning with NMDA or DHPG promotes differential neuroprotective mechanisms: NMDA by internalization of GluA1‐AMPA receptors, DHPG by producing the endocannabinoid 2‐AG.

Source: Journal of Neurochemistry - May 17, 2020 Category: Neuroscience Authors: Elisabetta Gerace, Elisa Zianni, Elisa Landucci, Tania Scartabelli, Rolando Berlinguer Palmini, Daniela Iezzi, Flavio Moroni, Monica Di Luca, Guido Mannaioni, Fabrizio Gardoni, Domenico E. Pellegrini ‐Giampietro Tags: ORIGINAL ARTICLE Source Type: research