Usefulness of Interleukin-1 Receptor Antagonists in Patients With Recurrent Pericarditis

Nonsteroidal anti-inflammatory drugs and colchicine remain the standard of care as the initial treatment of acute pericarditis. Corticosteroids and traditional immunosuppressive medications are often added if patients develop recurrent symptoms and remain medically refractory. There has been growing interest in the use of interleukin-1 receptor antagonists (IL-1RAs) in managing pericarditis, especially, in medically refractory cases. Anakinra-Treatment for Recurrent Idiopathic Pericarditis is a recent pilot trial showing a benefit of using the IL-1RA, anakinra, in recurrent pericarditis.

Source: The American Journal of Cardiology - April 6, 2020 Category: Cardiology Authors: Mohamed Khayata, Nishant P. Shah, Beni R. Verma, Aldo S. Giugni, Saqer Alkharabsheh, Craig R. Asher, Massimo Imazio, Allan L. Klein Source Type: research