Use of a homozygous G608G progeria mouse model for degenerative joint diseases research

(Beth Israel Deaconess Medical Center) In a study published today in the journal Proceedings of the National Academies of Science, researchers led by Ara Nazarian, PhD, a principal investigator in the Center for Advanced Orthopaedic Studies at BIDMC, investigated the musculoskeletal phenotype of the homozygous G608G BAC-transgenic progeria mouse model, developed at Dr. Collins' lab at the National Institutes of Health, and determined the phenotypic changes of these mice after a five-arm preclinical trial of different treatment combinations with lonafarnib, pravastatin, and zoledronic acid.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news