Functional alterations and transcriptomic changes during zebrafish cardiac aging.
In this study we first validated the effectiveness of a panel of aging-related markers and revealed their spatial-temporal specificity. Using these markers, we discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function. Furthermore, we showed aging-related expression profile change in zebrafish hearts was similar to that in rat hearts. Overall, our results provide a deeper insight into the cardiac aging process in zebrafish, which will set up foundation for generating novel cardiac aging models suitable for large scale screening of pharmaceutical targets.
PMID: 32372324 [PubMed - as supplied by publisher]
Source: Biogerontology - Category: Geriatrics Authors: Shao X, Fu Y, Ma J, Li X, Lu C, Zhang R Tags: Biogerontology Source Type: research