Impaired Autophagic Activity Contributes to the Pathogenesis of Bronchopulmonary Dysplasia: Evidence from Murine and Baboon Models.

CONCLUSIONS: Basal autophagy is induced during alveolarization and disrupted during progression of nHILI in mice and BPD in baboons. Becn1+/- mice are more susceptible to nHILI suggesting that preservation of autophagic activity may be an effective protective strategy in BPD.
PMID: 32374619 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory Cell and Molecular Biology - May 5, 2020 Category: Molecular Biology Authors: Zhang L, Soni S, Hekimoglu E, Berkelhamer S, Çataltepe S Tags: Am J Respir Cell Mol Biol Source Type: research