The Impact of Plant Bioactive Compounds on Aging and Fertility of Diverse Organisms: A Review.

The Impact of Plant Bioactive Compounds on Aging and Fertility of Diverse Organisms: A Review. Mini Rev Med Chem. 2020 Apr 28;: Authors: Noordin MAM, Noor MM, Aizat WM Abstract It is expected that in 2050 there will be more than 20% of senior citizens aged over 60 years worldwide. Such alarming statistics require immediate attention to improve the health of the aging population. Since aging is closely related to the loss of antioxidant defense mechanism, this situation will eventually lead to numerous health problems, including fertility reduction. Furthermore, plant extracts were used in traditional medicine as potent antioxidant sources. Despite many experiments had reported the impact of various bioactive compounds on aging or fertility, there is lack of review papers which combine both subjects. In this review, we have collected and discussed various bioactive compounds from 26 different plant species known to affect both longevity and fertility. These compounds including phenolics and terpenes, are mostly involved in the antioxidant defense mechanism of diverse organisms such as rats, mites, fruit flies, roundworms and even rooster. A human clinical trial should be considered in the future to measure the efficacy of these bioactive compounds on human health and longevity. Ultimately, these plant-derived compounds could be developed into health supplements or potential medical drugs to ensure a healthy aging population. P...
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research