Autism traits in the RASopathies

Conclusions Higher prevalence and severity of autism traits in RASopathies compared to unaffected siblings suggests that dysregulation of Ras/MAPK signalling during development may be implicated in ASD risk. Evidence for sex bias and potential sibling correlation suggests that autism traits in the RASopathies share characteristics with autism traits in the general population and clinical ASD population and can shed light on idiopathic ASDs.

http://jmg.bmj.com/cgi/content/short/51/1/10?rss=1

Source: Journal of Medical Genetics - December 18, 2013 Category: Genetics & Stem Cells Authors: Adviento, B., Corbin, I. L., Widjaja, F., Desachy, G., Enrique, N., Rosser, T., Risi, S., Marco, E. J., Hendren, R. L., Bearden, C. E., Rauen, K. A., Weiss, L. A. Tags: Editor's choice, Connective tissue disease Cognitive and behavioural genetics Source Type: research