Consequences of HSV-1-induced AS1 deficiency [Microbiology]

Herpes simplex virus 1 (HSV-1) infection triggers specific metabolic changes in its host cell. To explore the interactions between cellular metabolism and HSV-1 infection, we performed an siRNA screen of cellular metabolic genes, measuring their effect on viral replication. The screen identified multiple enzymes predicted to influence HSV-1 replication, including...

http://www.pnas.org/content/110/51/E5006.short?rss=1

Source: Proceedings of the National Academy of Sciences - December 17, 2013 Category: Science Authors: Grady, S. L., Purdy, J. G., Rabinowitz, J. D., Shenk, T. Tags: PNAS Plus Source Type: research