Co-occurrent Alterations of Alzheimer's Genes and Prostate Cancer Genes in Prostate Cancer

Conclusion: The severity of prostate cancer is determined by the genetics of the tumor itself, possibly at least in part by the interactions of SPOP/BIN1, MYC/BIN1 and SPTA1/CD2AP. Oncologists treats higher grade prostate cancer with more ADT, which serves as a surrogate marker for disease severity. A weakness of our study is that we did not examine Alzheimer's disease or dementia at all in patients with cancer, only co-occurrence of genetic alterations. Nevertheless, our analysis of TCGA data does not support the idea that ADT causes Alzheimer's disease or dementia.

Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: LEHRER, S., RHEINSTEIN, P. H. Tags: Article Source Type: research